Pub. Date : 2016 May
PMID : 26432904
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tacrolimus is a widely used immunosuppressive drug that inhibits the phosphatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12). | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 2 | When treated with tacrolimus, however, BP and the renal abundance of phosphorylated NCC were lower in mice lacking FKBP12 along the nephron than in control mice. | Tacrolimus | FK506 binding protein 1a | Mus musculus |
| 3 | Mice lacking FKBP12 along the nephron also maintained a normal relationship between plasma potassium levels and the abundance of phosphorylated NCC with tacrolimus treatment. | Tacrolimus | FK506 binding protein 1a | Mus musculus |