Pub. Date : 2015 Oct 27
PMID : 26430963
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | The re-expression of COX-2 was observed after 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment in both cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Further investigation found that H3K36 dimethylation was significantly reduced near the COX-2 promoter because histone demethylase 2A (KDM2A) was recruited to the COX-2 promoter after TPA treatment. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | In addition, the transcription factor c-Fos was found to be required to recruit KDM2A to the COX-2 promoter for reactivation of COX-2 in response to TPA treatment in both the H719 and H460 cell lines. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 7 | Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 8 | Together, our data reveal a novel mechanism by which the carcinogen TPA activates COX-2 expression by regulating H3K36 dimethylation near the COX-2 promoter. | Tetradecanoylphorbol Acetate | prostaglandin-endoperoxide synthase 2 | Homo sapiens |