Title : Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice.

Pub. Date : 2016 May

PMID : 26428091






4 Functional Relationships(s)
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1 Exposure to nicotine increases nicotinic acetylcholine receptor density in the reward pathway and binge ethanol consumption in C57BL/6J adolescent female mice. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Past studies report that nicotine and ethanol activate dopamine neurons in the reward pathway and may increase synaptic levels of dopamine in the nucleus accumbens through nicotinic acetylcholine receptor (nAChR) stimulation. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 Past studies report that nicotine and ethanol activate dopamine neurons in the reward pathway and may increase synaptic levels of dopamine in the nucleus accumbens through nicotinic acetylcholine receptor (nAChR) stimulation. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 Autoradiographic analysis of nAChR density revealed higher epibatidine binding in frontal cortical regions in mice exposed to nicotine and ethanol compared to mice exposed to ethanol only. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus