Title : Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation.

Pub. Date : 2015 Nov 6

PMID : 26416893






1 Functional Relationships(s)
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1 Mitochondrial dysfunction is considered crucial for NLRP3 inflammasome activation partly through its release of mitochondrial toxic products, such as mitochondrial reactive oxygen species (mROS)(2) and mitochondrial DNA (mtDNA). Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens