Title : Diethylstilbestrol-scaffold-based pregnane X receptor modulators.

Pub. Date : 2015 Oct 20

PMID : 26408814






1 Functional Relationships(s)
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1 The PXR modulatory effects of the synthesized diethylstilbestrol derivatives were further confirmed by the induction of PXR-regulated CYP3A4 expression with compound 1, as well as by the inhibition of the rifaximin-promoted up-regulation of CYP3A4 expression with 2 and its derivative 6. Rifaximin nuclear receptor subfamily 1 group I member 2 Homo sapiens