Pub. Date : 2015 Dec 1
PMID : 26404748
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Safety profile of mineralocorticoid receptor antagonists: Spironolactone and eplerenone. | Eplerenone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 2 | Spironolactone was first developed over 50 years ago as a potent mineralocorticoid receptor antagonist with undesirable side effects; it was followed a decade ago by eplerenone, which is less potent but much more mineralocorticoid receptor-specific. | Eplerenone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 3 | Due to the selectivity of eplerenone for the aldosterone receptor, severe adverse effects such as gynecomastia and vaginal bleeding seem to be less likely in patients who take eplerenone than in those who take spironolactone. | Eplerenone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 4 | Due to the selectivity of eplerenone for the aldosterone receptor, severe adverse effects such as gynecomastia and vaginal bleeding seem to be less likely in patients who take eplerenone than in those who take spironolactone. | Eplerenone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |