Pub. Date : 2015 Oct
PMID : 26398380
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Working memory deficits and alterations of ERK and CREB phosphorylation following withdrawal from cocaine self-administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | Upon T-maze training and 8-week withdrawal, cocaine-pretreated rats had higher levels of p-CREB/CREB in prefrontal cortex and dorsal striatum and lower in hippocampus compared to saline rats. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | Upon T-maze training and 8-week withdrawal, cocaine-pretreated rats had higher levels of p-CREB/CREB in prefrontal cortex and dorsal striatum and lower in hippocampus compared to saline rats. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | CONCLUSION: Our results suggest that cocaine self-administration results in cognitive impairments and alterations in ERK/CREB signaling pathway long after discontinuation of drug use. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |