Title : Reversing Antisense Oligonucleotide Activity with a Sense Oligonucleotide Antidote: Proof of Concept Targeting Prothrombin.

Pub. Date : 2015 Dec

PMID : 26390010






1 Functional Relationships(s)
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1 The antithrombotic activity of prothrombin ASOs was demonstrated in a FeCl3-induced thrombosis mouse model, and as predicted for this target, the doses required for antithrombotic activity were also associated with increased bleeding. ferric chloride coagulation factor II Mus musculus