Title : Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells.

Pub. Date : 2016 Feb

PMID : 26386720






1 Functional Relationships(s)
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1 In five of the six cell lines, LPA induced phosphorylation of the EGFR, and the effects on EGFR and Akt, and in some of the cells also ERK, were sensitive to the EGFR tyrosine kinase inhibitor gefitinib, strongly suggesting LPA-induced EGFR transactivation in these cells. lysophosphatidic acid AKT serine/threonine kinase 1 Homo sapiens