Title : Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug-Drug Interactions.

Pub. Date : 2016 Mar

PMID : 26385839






1 Functional Relationships(s)
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1 It performed well in recovering the observed effect of the CYP3A4 inhibitors ketoconazole and cyclosporine, and the CYP3A4 inducer rifampicin, as well as in predicting interactions with S-warfarin and sildenafil. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens