Title : GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer - Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation.

Pub. Date : 2015 Dec

PMID : 26385428






2 Functional Relationships(s)
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1 We show that inhibition of GSK3beta with lithium chloride enhances Gli3 processing into its repressor form, consequently downregulating Hh-Gli signaling, reducing cell proliferation and inducing cell death. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens
2 Analysis of the molecular mechanisms revealed that lithium chloride enhances Gli3-SuFu-GSK3beta complex formation leading to more efficient Gli3 cleavage and Hh-Gli signaling downregulation. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens