Pub. Date : 2015 Nov
PMID : 26381451
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Currently available anti-FPPS drugs are active-site-directed bisphosphonate inhibitors, the peculiar pharmacological profile of which is inadequate for therapeutic indications beyond bone diseases. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 2 | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
| 3 | The recent discovery of an allosteric binding site has paved the way toward the development of novel non-bisphosphonate FPPS inhibitors with broader therapeutic potential, notably as immunomodulators in oncology. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |