Title : Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.

Pub. Date : 2015 Oct

PMID : 26377631






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 P281L MUTYH was found to be severely compromised both in DNA binding and base excision activity, consistent with the location of this variation in the iron-sulfur cluster (FCL) DNA binding motif of MUTYH. Iron mutY DNA glycosylase Homo sapiens
2 P281L MUTYH was found to be severely compromised both in DNA binding and base excision activity, consistent with the location of this variation in the iron-sulfur cluster (FCL) DNA binding motif of MUTYH. Iron mutY DNA glycosylase Homo sapiens