Title : Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.

Pub. Date : 2015 Oct

PMID : 26377631






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MUTYH is a base excision repair (BER) enzyme that prevents mutations in DNA associated with 8-oxoguanine (OG) by catalyzing the removal of adenine from inappropriately formed OG:A base-pairs. Adenine mutY DNA glycosylase Homo sapiens
2 Both R295C and R520Q MUTYH were found to have low fractions of active enzyme, compromised affinity for damaged DNA, and reduced rates for adenine excision. Adenine mutY DNA glycosylase Homo sapiens