Title : Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury.

Pub. Date : 2015 Nov

PMID : 26377490






1 Functional Relationships(s)
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1 CONCLUSION: The renoprotective effect of sildenafil against renal I/R might be due to the activation of antioxidant genes (Nrf2, HO-1 and NQO-1) and antiapoptotic gene (Bcl2) and attenuation of proinflammatory cytokines (TNF-a, IL-1beta and ICAM-1). Sildenafil Citrate tumor necrosis factor Rattus norvegicus