Title : Activation of canonical Wnt/β-catenin signaling inhibits H2O2-induced decreases in proliferation and differentiation of human periodontal ligament fibroblasts.

Pub. Date : 2016 Jan

PMID : 26369531






4 Functional Relationships(s)
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1 Osteoblastic differentiation of hPLFs was also inhibited by combined treatment with 100 muM H2O2, as evidenced by the decreases in alkaline phosphatase (ALP) activity and mineralization. Hydrogen Peroxide alkaline phosphatase, placental Homo sapiens
2 Osteoblastic differentiation of hPLFs was also inhibited by combined treatment with 100 muM H2O2, as evidenced by the decreases in alkaline phosphatase (ALP) activity and mineralization. Hydrogen Peroxide alkaline phosphatase, placental Homo sapiens
3 Furthermore, siRNA-mediated silencing of Nrf2 blocked H2O2-induced decreases in ALP activity and mineralization of hPLFs with the concomitant restoration of runt-related transcription factor 2 and osteocalcin mRNA expression and ALP activity. Hydrogen Peroxide alkaline phosphatase, placental Homo sapiens
4 Furthermore, siRNA-mediated silencing of Nrf2 blocked H2O2-induced decreases in ALP activity and mineralization of hPLFs with the concomitant restoration of runt-related transcription factor 2 and osteocalcin mRNA expression and ALP activity. Hydrogen Peroxide alkaline phosphatase, placental Homo sapiens