Title : Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis.

Pub. Date : 2015 Nov

PMID : 26363031






2 Functional Relationships(s)
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1 When p53 and Rb were turned down, the FF-exposed secretory cells overcame apoptosis and expanded the population carrying ROS and DSB. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 The study revealed ROS and mitogens in mature ovarian follicles could initiate the transformation of fimbria epithelium in the context of p53 loss and melatonin is a potent preventive agent. Reactive Oxygen Species tumor protein p53 Homo sapiens