Title : Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy.

Pub. Date : 2015 Sep 11

PMID : 26362310






5 Functional Relationships(s)
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Protein Name
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1 In breast cell lines, doxorubicin induced MRP1 expression and function (non-linear regression p < 0.004). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
2 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
3 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
4 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens
5 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). Doxorubicin ATP binding cassette subfamily C member 1 Homo sapiens