Title : Induction of glutathione S-transferase by phenobarbital in rat hepatocyte culture.

Pub. Date : 1989 Dec

PMID : 2635735






7 Functional Relationships(s)
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1 Induction of glutathione S-transferase by phenobarbital in rat hepatocyte culture. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
2 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
3 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
4 Treatment of hepatocytes with a medium containing 6 or 8 mM phenobarbital for 20 h increased the specific activity of GST approx. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
5 When induction of GST by phenobarbital treatment was observed, the cellular level of phenobarbital determined by HPLC was approx. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
6 When induction of GST by phenobarbital treatment was observed, the cellular level of phenobarbital determined by HPLC was approx. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus
7 Thus, an inductive effect of phenobarbital on GST was observed in vitro as well as in rat liver. Phenobarbital hematopoietic prostaglandin D synthase Rattus norvegicus