Pub. Date : 2016 Feb
PMID : 26353895
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simeprevir is metabolized by the cytochrome P450 (CYP) system, primarily CYP3A, and is a substrate for several drug transporters, including the organic anion transporting polypeptides (OATPs). | Simeprevir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | It is susceptible to metabolic drug-drug interactions with drugs that are moderate or strong CYP3A inhibitors (e.g. ritonavir and erythromycin) or CYP3A inducers (e.g. rifampin and efavirenz); coadministration of these drugs may increase or decrease plasma concentrations of simeprevir, respectively, and should be avoided. | Simeprevir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Clinical studies have shown that simeprevir is a mild inhibitor of CYP1A2 and intestinal CYP3A but does not inhibit hepatic CYP3A. | Simeprevir | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |