Pub. Date : 2015 Nov
PMID : 26352537
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the beta-catenin pathway. | Lithium Chloride | catenin beta 1 | Rattus norvegicus |
| 2 | These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway. | Lithium Chloride | catenin beta 1 | Rattus norvegicus |
| 3 | These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway. | Lithium Chloride | catenin beta 1 | Rattus norvegicus |
| 4 | However, as demonstrated by our findings, LiCl reduces abnormal adipogenic activity and simultaneously increases the osteogenic differentiation of ONFH-BMMSCs by activating the beta-catenin pathway. | Lithium Chloride | catenin beta 1 | Rattus norvegicus |