Title : Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin.

Pub. Date : 2015 Nov

PMID : 26344902






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 By contrast, inhibition of AMPK phosphorylation by Compound C worsened palmitate-induced changes and correspondingly blocked the protective effect of oleate. Oleic Acid protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
2 Oleate reverses these effects through a metformin-like facilitation of AMPK. Oleic Acid protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens