Title : The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.

Pub. Date : 2015 Oct 23

PMID : 26342080






1 Functional Relationships(s)
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1 The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase. deoxyguanosine triphosphate deoxyguanosine kinase Homo sapiens