Pub. Date : 2015 Oct 23
PMID : 26342080
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Down-regulation of SAMHD1 by siRNA expands all four dNTP pools, with dGTP undergoing the largest relative increase. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 2 | The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 3 | We studied if SAMHD1 and dGK interact in the regulation of the dGTP pool during quiescence employing dGK-mutated skin fibroblasts derived from three unrelated patients. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 4 | Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 5 | Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. | deoxyguanosine triphosphate | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |