Title : The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.

Pub. Date : 2015 Oct 23

PMID : 26342080






3 Functional Relationships(s)
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1 The deoxyguanosine released by SAMHD1 from dGTP can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol by purine nucleoside phosphorylase. deoxyguanosine triphosphate Diacyl glycerol kinase Drosophila melanogaster
2 We studied if SAMHD1 and dGK interact in the regulation of the dGTP pool during quiescence employing dGK-mutated skin fibroblasts derived from three unrelated patients. deoxyguanosine triphosphate Diacyl glycerol kinase Drosophila melanogaster
3 Our results prove the importance of SAMHD1 in the regulation of all dNTP pools and suggest that dGK inside mitochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by SAMHD1 in the nucleus. deoxyguanosine triphosphate Diacyl glycerol kinase Drosophila melanogaster