Title : [Molecular Biological Analysis of Factors Influencing Pharmacokinetics to Achieve Personalized Pharmacotherapy].

Pub. Date : 2015

PMID : 26329549






4 Functional Relationships(s)
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1 The first finding is that the oral bioavailability of cyclosporine A (CsA), which is an immunosuppressant, was decreased by increased first-pass metabolism due to elevated CYP3A and P-glycoprotein (P-gp) specifically in the upper small intestine after liver I/R. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 The first finding is that the oral bioavailability of cyclosporine A (CsA), which is an immunosuppressant, was decreased by increased first-pass metabolism due to elevated CYP3A and P-glycoprotein (P-gp) specifically in the upper small intestine after liver I/R. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
3 The first finding is that the oral bioavailability of cyclosporine A (CsA), which is an immunosuppressant, was decreased by increased first-pass metabolism due to elevated CYP3A and P-glycoprotein (P-gp) specifically in the upper small intestine after liver I/R. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
4 The first finding is that the oral bioavailability of cyclosporine A (CsA), which is an immunosuppressant, was decreased by increased first-pass metabolism due to elevated CYP3A and P-glycoprotein (P-gp) specifically in the upper small intestine after liver I/R. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus