Pub. Date : 1989 Dec
PMID : 2632718
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vasopressin and water distribution in rats with DOCA-salt hypertension. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 2 | The chronic DOCA-salt treatment caused a marked hypertension in vasopressin-synthesizing animals; in these animals body water was slightly increased due to the expansion of extra-cellular fluid volume whereas intracellular water tended to decrease, so that the ratio of extracellular fluid volume to intracellular water rose significantly. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 3 | The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 4 | The development of DOCA-salt hypertension was attenuated in the vasopressin-deficient rats, which had a similar level of total body water, slightly increased intracellular water and significantly decreased extracellular fluid volume compared with the hypertensive vasopressin-synthesizing rats. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 5 | Unaltered total body water together with elevated plasma osmolality indicated an extracellular water deficiency in DOCA-salt-treated vasopressin-deficient rats. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 6 | Chronic dDAVP supplementation restored the body fluid pattern and the hypertensive response of the DOCA-salt-treated vasopressin-deficient rats. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |
| 7 | In conclusion, the antidiuretic effects of vasopressin are necessary for the interstitial fluid volume expansion that is essential for a full development of DOCA-salt hypertension. | Desoxycorticosterone Acetate | arginine vasopressin | Rattus norvegicus |