Pub. Date : 2016 Apr
PMID : 26324408
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. | Cocaine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | This study tests the hypothesis that activation of 5-HT1A autoreceptors, which would lessen 5-HT neuron firing, contributes to cocaine-seeking behaviors. | Cocaine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | Finally, using a rat model of compulsive-like cocaine self-administration, we found that inhibition of dorsal raphe 5-HT1A autoreceptors attenuates cocaine self-administration in rats with 6 h extended access, but not 1 h access to the drug. | Cocaine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 4 | Finally, using a rat model of compulsive-like cocaine self-administration, we found that inhibition of dorsal raphe 5-HT1A autoreceptors attenuates cocaine self-administration in rats with 6 h extended access, but not 1 h access to the drug. | Cocaine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 5 | Therefore, our findings suggest an important role for 5-HT1A autoreceptors, and thus DRN NAc 5-HT neuronal activity, in the etiology and vulnerability to cocaine reward and addiction. | Cocaine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |