Title : Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.

Pub. Date : 2015 Sep 1

PMID : 26324318






1 Functional Relationships(s)
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1 These cytokines and LPS can induce P-gp expression through the STAT3/Nf-kappab pathway, contributing to a decrease of cyclosporine A retention, which can be reversed by the application of a P-gp inhibitor. Cyclosporine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus