Title : Simvastatin Inhibits Toll-like Receptor 8 (TLR8) Signaling in Primary Human Monocytes and Spontaneous Tumor Necrosis Factor Production from Rheumatoid Synovial Membrane Cultures.

Pub. Date : 2015 Nov

PMID : 26322850






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A short pretreatment with simvastatin dose-dependently inhibited the production of tumor necrosis factor (TNF)-alpha in response to TLR8 activation (but not TLR2, -4 or -5). Simvastatin tumor necrosis factor Homo sapiens
2 Simvastatin significantly inhibited the spontaneous release of TNF in this model, which was not reversed by mevalonate. Simvastatin tumor necrosis factor Homo sapiens