Title : Species and mediator specific TLR4 antagonism in primary human and murine immune cells by βGlcN(1↔1)αGlc based lipid A mimetics.

Pub. Date : 2015 Oct

PMID : 26319313






1 Functional Relationships(s)
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1 In order to inhibit TLR4 driven immune activation we recently developed synthetic tetra-acylated lipid A mimetics based on a conformationally restricted betaGlcN(1 1)alphaGlcN disaccharide scaffold (DA-compounds) that antagonized ectopically overexpressed human and murine TLR4/MD-2 complexes. Lipid A lymphocyte antigen 96 Mus musculus