Title : Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.

Pub. Date : 2015 Aug 26

PMID : 26308581






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. polyglutamine androgen receptor Mus musculus
2 Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. polyglutamine androgen receptor Mus musculus
3 Specifically, we have found that NLK can phosphorylate the mutant polyglutamine-expanded AR, enhance its aggregation, and promote AR-dependent gene transcription by regulating AR-cofactor interactions. polyglutamine androgen receptor Mus musculus
4 Specifically, we have found that NLK can phosphorylate the mutant polyglutamine-expanded AR, enhance its aggregation, and promote AR-dependent gene transcription by regulating AR-cofactor interactions. polyglutamine androgen receptor Mus musculus