Title : Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children.

Pub. Date : 2015 Nov

PMID : 26303110






2 Functional Relationships(s)
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Protein Name
Organism
1 CDRLTG values of the patients carrying the UGT1A4*3 genotype were higher compared to UGT1A4*1*1 (2.86 +- 1.03 vs 2.22 +- 0.94 mug/mL per mg/kg, p = 0.001) only when the VPA concentration was higher. Valproic Acid UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 CONCLUSIONS: UGT1A4*3 polymorphism had an effect on LTG concentration only with VPA co-administration, and the effect was remarkable when VPA concentration was higher. Valproic Acid UDP glucuronosyltransferase family 1 member A4 Homo sapiens