Title : A novel mechanism for the anticonvulsant effect of furosemide in rat hippocampus in vitro.

Pub. Date : 2015 Nov 2

PMID : 26301821






1 Functional Relationships(s)
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1 Based on these results we propose that the anticonvulsant action of furosemide in the Cs(+)-model is exerted through blockade of the neuronal KCC2 and Na(+)-independent Cl(-)/HCO3(-)-exchanger (AE3) leading to stabilization of the activity-induced intracellular acidification in CA1 pyramidal neurons. Furosemide solute carrier family 12 member 5 Rattus norvegicus