Title : In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib.

Pub. Date : 2015 Dec 1

PMID : 26296860






1 Functional Relationships(s)
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1 Investigation of inhibitory potency towards 6 CYP isoforms generally revealed low inhibitory potency, but in the case of CYP3A4, a substrate dependent inhibition was noted using testosterone as substrate (IC50: 12.5muM). Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens