Title : Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.

Pub. Date : 2016

PMID : 26295831






4 Functional Relationships(s)
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1 Using a SCA3 ATXN3/Q75-GFP cell model, we found that the ATXN3/Q75 aggregation was significantly prohibited by lactulose and melibiose because of their abilities to up-regulate autophagy. Lactulose ataxin 3 Homo sapiens
2 Using a SCA3 ATXN3/Q75-GFP cell model, we found that the ATXN3/Q75 aggregation was significantly prohibited by lactulose and melibiose because of their abilities to up-regulate autophagy. Lactulose ataxin 3 Homo sapiens
3 Using a SCA3 ATXN3/Q75-GFP cell model, we found that the ATXN3/Q75 aggregation was significantly prohibited by lactulose and melibiose because of their abilities to up-regulate autophagy. Lactulose ataxin 3 Homo sapiens
4 Meanwhile, lactulose and melibiose reduced reactive oxygen species production in ATXN3/Q75 cells. Lactulose ataxin 3 Homo sapiens