Title : 15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies.

Pub. Date : 2015 Aug 17

PMID : 26287183






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression. dhts mitogen-activated protein kinase 8 Homo sapiens
2 DHTS induced sustained c-Jun N-terminal kinase (JNK) phosphorylation and Fas ligand (FasL) expression. dhts mitogen-activated protein kinase 8 Homo sapiens
3 The anti-Fas blocking antibody reversed the DHTS-induced cell death, and the JNK-specific inhibitor, SP600125, inhibited DHTS-induced caspase-3, -8, -9, and PARP cleavage. dhts mitogen-activated protein kinase 8 Homo sapiens
4 Taken together, these results suggest that DHTS can induce HL-60 cell apoptosis in vitro and inhibit HL-60 cell growth in vivo; the underlying mechanisms might be mediated through activation of the JNK and FasL signal pathways. dhts mitogen-activated protein kinase 8 Homo sapiens