Pub. Date : 2016 Jan
PMID : 26276860
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21. | Methyl Methanesulfonate | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Trx1 overexpression and small interfering RNA knockdown in cells revealed that reduced Trx1 after exposure to lower doses of MMS attenuated DNA damage, assessed by comet assay, and level of the DNA-damage marker histone gamma-H2AX, possibly through scavenging intracellular ROS and an increase in p21 protein level via enhancing its stability. | Methyl Methanesulfonate | H3 histone pseudogene 16 | Homo sapiens |