Pub. Date : 2015 Dec
PMID : 26271661
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A5*3, CYP3A4*1B and CYP3A4*22 alleles of liver grafts may explain about one third of the inter-individual differences in pharmacokinetics of ciclosporin and tacrolimus in recipients. | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | RESULTS: The recipients with grafts from normal CYP3A4 expresser donors carrying CYP3A5*3/*3 required CNI maintenance doses more or less similar to the bodyweight-controlled starting doses (9.1 mg kg(-1) of ciclosporin and 0.1 mg kg(-1) of tacrolimus). | Cyclosporine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |