Pub. Date : 2015 Oct
PMID : 26264138
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P53 overproduction led to transcriptional downregulation of some yeast genes, such as the TRX1/2 thioredoxin system, which plays a key role in cell protection against various oxidative stresses induced by reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | P53 overproduction led to transcriptional downregulation of some yeast genes, such as the TRX1/2 thioredoxin system, which plays a key role in cell protection against various oxidative stresses induced by reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, measurements of ROS amounts by flow cytometry and fluorescence microscopy indicated that the TRX2 protein acted probably through its increased detoxifying activity on the P53-generated ROS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | Furthermore, measurements of ROS amounts by flow cytometry and fluorescence microscopy indicated that the TRX2 protein acted probably through its increased detoxifying activity on the P53-generated ROS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | Our data strengthen the idea that overexpression of a single gene (trx2) decreases the p53-mediated cell death by decreasing ROS accumulation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |