Pub. Date : 2015 Sep 8
PMID : 26262434
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Substrate-competitive ABPP analysis identified carboxylesterase 1 (CES1) as an oseltamivir-activating enzyme in intestinal cell homogenates. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 2 | Substrate-competitive ABPP analysis identified carboxylesterase 1 (CES1) as an oseltamivir-activating enzyme in intestinal cell homogenates. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 3 | Saturating concentrations of oseltamivir lead to a four-fold reduction in the observed rate constant for CES1 inactivation by fluorophosphonates. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 4 | WWL50, a reported carbamate inhibitor of mouse CES1, blocked oseltamivir hydrolysis activity in human cell homogenates, confirming CES1 is the primary prodrug activating enzyme for oseltamivir in human liver and intestinal cell lines. | Oseltamivir | carboxylesterase 1 | Homo sapiens |