Title : Evidence that removal of an endogenous metal that stabilizes the untransformed glucocorticoid receptor in cytosol allows ligand-independent receptor transformation.

Pub. Date : 1989

PMID : 2626024






1 Functional Relationships(s)
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1 When an L-cell cytosol preparation containing the glucocorticoid receptor is passed through a column of Chelex-100 resin and then incubated at 15 degrees C, the receptor is rapidly transformed to the DNA-binding state, regardless of whether it is steroid-bound or not. Steroids nuclear receptor subfamily 3 group C member 1 Homo sapiens