Title : Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

Pub. Date : 2015 Oct

PMID : 26254735






1 Functional Relationships(s)
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1 This effect was accompanied by reduction of AICD and Ptch1 levels and was prevented by inhibition of the Shh pathway with cyclopamine. cyclopamine sonic hedgehog Mus musculus