CPRiL

3 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	In this work, we conducted coarse-grained simulation to investigate the interactions of binding units of chorela toxin (CTB) with mixed ganglioside GM1 and dipalmitoylphosphatidylcholine (DPPC) lipid bilayer membrane.	G(M1) Ganglioside	chitobiase	Homo sapiens
2	We determine that the binding of CTB pentamers cross-links GM1 molecules into protein-sized nanodomains that have distinct lipid order compared with the bulk.	G(M1) Ganglioside	chitobiase	Homo sapiens
3	Comparison simulations on CTB binding to a membrane that is composed of various lipid components demonstrate that several factors are responsible for the nanodomain formation: (a) the negatively charged headgroup of a GM1 receptor is responsible for the multivalent binding; (b) the head groups being full of hydrogen-bonding donors and receptors stabilize the GM1 cluster itself and ensure the toxin binding with high affinity; and	G(M1) Ganglioside	chitobiase	Homo sapiens