Title : Induction of cytotoxicity from fresh splenocytes after in vivo administration of cyclophosphamide. Importance of long-term culture with high-dose recombinant interleukin-2.

Pub. Date : 1989

PMID : 2624921






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cyclophosphamide, combined with lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2), is known to mediate regression of tumors, but the effects of cyclophosphamide on the subsequent generation of LAK cells are unclear. Cyclophosphamide interleukin 2 Rattus norvegicus
2 It was the aim of the experiments in this paper to determine whether fresh splenocytes cultured with rIL-2 would maintain or regain their cytotoxicity in vitro after being exposed to the cytotoxic agent cyclophosphamide in vivo. Cyclophosphamide interleukin 2 Rattus norvegicus
3 It is concluded that murine splenocytes can demonstrate cytotoxicity after exposure to cyclophosphamide, through prolonged continuous in vitro culture with rIL-2. Cyclophosphamide interleukin 2 Rattus norvegicus