Title : Silencing of miR-21 sensitizes CML CD34+ stem/progenitor cells to imatinib-induced apoptosis by blocking PI3K/AKT pathway.

Pub. Date : 2015 Oct

PMID : 26248946






1 Functional Relationships(s)
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1 MiR-21 or PI3K inhibitor in combination with imatinib treatment significantly decreased AKT phosphorylation and c-Myc expression than either agent did alone, but did not affect Bim and Bcl-6 expresssion. Imatinib Mesylate MYC proto-oncogene, bHLH transcription factor Homo sapiens