Pub. Date : 2015 Oct
PMID : 26248946
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silencing of miR-21 sensitizes CML CD34+ stem/progenitor cells to imatinib-induced apoptosis by blocking PI3K/AKT pathway. | Imatinib Mesylate | CD34 molecule | Homo sapiens |
| 2 | Furthermore, PI3K inhibitors also significantly sensitized CML CD34+ cells to imatinib-induced apoptosis. | Imatinib Mesylate | CD34 molecule | Homo sapiens |
| 3 | These findings indicate that miR-21 is required for maintaining the imatinib-resistant phenotype of CML CD34+ cells through PI3K/AKT signaling pathway, thus providing the basis for a promising therapeutic approach to eliminate CML LSCs. | Imatinib Mesylate | CD34 molecule | Homo sapiens |