Title : Heat shock protein 90 inhibition abrogates TLR4-mediated NF-κB activity and reduces renal ischemia-reperfusion injury.

Pub. Date : 2015 Aug 7

PMID : 26248657






2 Functional Relationships(s)
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1 Cells were pre-treated with AT13387 and exposed to endotoxin-free hyaluronan to stimulate sterile TLR4-specific NF-kappaB inflammatory activation. Hyaluronic Acid toll like receptor 4 Homo sapiens
2 In vitro, AT13387-treatment resulted in breakdown of IkappaB kinase, which abolished TLR4-mediated NF-kappaB activation by hyaluronan. Hyaluronic Acid toll like receptor 4 Homo sapiens