Title : Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin.

Pub. Date : 2015 Dec

PMID : 26245802






3 Functional Relationships(s)
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1 We assessed the effect of metformin on down-regulating the NET mtDNA-PDC-IFNalpha pathway. Metformin interferon alpha 1 Homo sapiens
2 Metformin decreased PMA-induced NET formation and CpG-stimulated PDC IFNalpha generation. Metformin interferon alpha 1 Homo sapiens
3 CONCLUSION: Our findings establish a link between mtDNA in NETs, anti-mtDNA antibodies, and PDC IFNalpha pathogenesis in SLE, and highlight that specific strategies to down-regulate this pathway, such as treatment with metformin, may be new approaches to treat SLE. Metformin interferon alpha 1 Homo sapiens