Title : Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells.

Pub. Date : 2015 Oct

PMID : 26241492






2 Functional Relationships(s)
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1 We found that PMA-induced megakaryocytic differentiation in myeloid leukemia cells is accompanied by cell death and SOD1 down-regulation, while SOD2 expression is not affected. Tetradecanoylphorbol Acetate superoxide dismutase 1 Homo sapiens
2 The role of SOD1 is verified when ATN-224, a SOD1 specific inhibitor, inhibits cell proliferation and promotes cell death in myeloid leukemia cells without PMA treatment. Tetradecanoylphorbol Acetate superoxide dismutase 1 Homo sapiens